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Article

ROS-induced allosteric modulation of NikR promotes Helicobacter pylori biofilm formation by attenuating FlgR-dependent inhibition of the molybdate transport system.

Virulence - 1 Dec 2025

Zheng Yantong, Li Shutong, Xue Junyuan, Zhang Lu, Wang Liyuan, Zhao Yican, Zhang Wenxin, Ma Wenyue, Liu Jinmeng, Sun Yanlin, Sun Yundong

Abstract excerpt

Helicobacter pylori biofilm formation is crucial for its persistence and transmission, constituting a notable public health concern. Understanding the regulatory mechanisms driving biofilm initiation is vital for developing effective control strategies. This study reveals a previously uncharacterized regulatory mechanism where reactive oxygen species (ROS) promote H. pylori biofilm formation by modulating the key...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41225722
DOI: 10.1080/21505594.2025.2589562
PMCID: PMC12622350

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