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A machine learning framework for classifying dementia risk in mild cognitive impairment: evidence from a Korean genome-wide association study cohort.

Alzheimer's research & therapy - 10 Nov 2025

Cho Myeongji, Ban Hyo-Jeong, Nam Hye Ryeong, Chu Chang Hee, Jeon Jae Pil, Kim Sang Cheol

Abstract excerpt

BACKGROUND: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that presents challenges for early detection and intervention. Mild cognitive impairment (MCI), a critical precursor of AD, progresses to dementia in a substantial proportion of individuals annually. Genetic factors, particularly single nucleotide polymorphisms (SNPs), play a key role in the pathogenesis of AD, as identified by...

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PMID: 41214767
DOI: 10.1186/s13195-025-01894-5
PMCID: PMC12604216

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