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Exploring the comorbidity mechanism of rheumatoid arthritis and systemic lupus erythematosus through transcriptomics and conducting experimental validation.

Clinical and experimental rheumatology - 1 May 2026

Shen Minghui, You Chongge

Abstract excerpt

OBJECTIVES: Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are two systemic autoimmune diseases with significant comorbidity, and the shared molecular mechanisms remain unclear. METHODS: This study integrates four transcriptomic datasets (GSE17755, GSE110169, GSE93272, GSE110174), combining differential expression gene (DEG) screening, protein-protein interaction (PPI) network analysis, machine...

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Arthritis, Rheumatoid
Comorbidity
Databases, Genetic
Gene Regulatory Networks
Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Protein Interaction Maps

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Identifiers

PMID: 41196273
DOI: 10.55563/clinexprheumatol/1xlydo

Genes

TNFSF13B
ZCCHC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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