Article
Research progress of direct and indirect KRAS-targeting protein degraders in KRAS-mutant cancers.
Bioorganic chemistry - 1 Nov 2025
Jiang Lili, Chen Yingxiang, Zhao Jinkai, Zhou Liqin, Zhou Qingwei, Jiang Haobin, Lou Dayong, Huang Wenhai, Zhang Yefei
Abstract excerpt
The RAS gene, being the most frequently activated proto-oncogene, belongs to the GTPase family. Its primary physiological function is to regulate cell proliferation. The main members of the RAS gene are H-RAS, K-RAS, and N-RAS. Approximately 16 % of human cancers are related to RAS proteins. KRAS is the most common oncogene. About 17 % of solid tumors have KRAS mutations, which account for around 50 %, 80 %, and...
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