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The phenotypic variation of widefins medaka is due to the insertion of a giant transposon containing a viral genome within the hoxca cluster.

Genetics - 10 Dec 2025

Koita Rina, Otake Shunsuke, Fukaya Natsuki, Yamamoto Kenji, Maeno Akiteru, Kanno Haruna, Matsuda Masaru, Kawamura Akinori

Abstract excerpt

Phenotypic variation in species arises from genetic differences and environmental influences on gene expression. Differences in epigenetic modifications, such as histone modifications and DNA methylation, can also contribute to phenotypic variations, even among individuals with identical genetic information. However, the underlying molecular mechanisms are not yet fully understood, particularly in vertebrates....

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PMID: 41052773
DOI: 10.1093/genetics/iyaf218
PMCID: PMC12693550

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