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Cascade Testing Among Patients With Breast Cancer: Current Situation and Challenges in Latin America.

JCO global oncology - 1 Sept 2025

Alvarez-Gómez Rosa María, Garcilazo-Reyes Alexandra, Avila-Moreno Federico, Arrieta-Rodriguez Oscar Gerardo, Cabrera Galeana Paula Anel, Arce-Salinas Claudia Haydeé

Abstract excerpt

PURPOSE: Breast cancer is a significant public health issue worldwide, with a particularly high impact in Latin America (LATAM). Genetic risk assessment and germline molecular testing for pathogenic variants in actionable genes are established practices for managing breast cancer risk. Cascade testing, genetic testing of at-risk relatives of individuals carrying these variants, provides a pivotal strategy for...

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PMID: 41021877
DOI: 10.1200/GO-24-00387

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