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Article

Genomic epidemiology of mpox virus during the 2022 outbreak in New York City.

Nature communications - 24 Sept 2025

Akther Saymon, Su Michelle, Wang Jade C, Amin Helly, Taki Faten, De La Cruz Nelson, Chowdhury Moinuddin, Clabby Tyler, Kopping Erik, Ruiz Victoria E, Leelawong Mindy, Latash Julia, Johnson Kimberly, Baumgartner Jennifer, Wong Marcia, Olsen Aaron, Fowler Randal C, Pekar Jonathan E, Havens Jennifer L, Vasylyeva Tetyana I, Wertheim Joel O, Hughes Scott, Omoregie Enoma

Abstract excerpt

New York City (NYC) was a major hotspot during the 2022 multi-country Mpox virus (MPXV) outbreak in the U.S. To investigate the genomic characteristics of MPXV in NYC, we sequenced 1138 specimens from 758 individuals using PrimalSeq and Illumina technology and performed phylogenomic analyses alongside 2967 global MPXV sequences. Nextclade lineage assignment revealed a NYC-specific B.1.12 lineage, with...

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Identifiers

PMID: 40993147
DOI: 10.1038/s41467-025-60486-x
PMCID: PMC12460763

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