Article
Multimodal MRI analysis selecting key brain features for machine learning based classification of diabetic neuropathic pain and phenotypes.
Journal of the neurological sciences - 15 Nov 2025
Hostrup Søren Nf, Lind Henrik P, Croosu Suganthiya S, Røikjer Johan, Mørch Carsten D, Ejskjær Niels, Østergaard Lasse R, Hansen Tine M, Frøkjær Jens B
Abstract excerpt
Cerebral alterations are associated with diabetic peripheral neuropathy (DPN) and neuropathic pain, including reductions in brain volumes, cortical thickness, sulcus depth, and alterations in metabolites and functional connectivity. This study combined multimodal magnetic resonance imaging (MRI) data to differentiate clinical phenotypes and uncover distinct associated brain features using machine-learning based...
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