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Identifying pyroptosis-hub genes and immune infiltration in neonatal hypoxic-ischemic brain injury

5 Sept 2025

Abstract excerpt

Background: Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal brain injury and neurodevelopmental disorders. Pyroptosis, an inflammatory programmed cell death, may offer new therapeutic targets for HIE by modulating cytokine expression and related pathways. This study aims to identify HIE-associated pyroptosis genes and explore potential drugs and molecular mechanisms. Methods: The gene...

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Share to Heme Oxygenase-1 and Carbon Monoxide
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PMID: 40977739
DOI: 10.3389/fimmu.2025.1616312

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