Cyclic-di-GMP signalling mutants drive ecological succession and self-generated diversity in experimentally evolved biofilms of Pseudomonas aeruginosa.

Abstract excerpt

Biofilms represent a discrete form of microbial life which are physiologically distinct from free-living planktonic cells. The altered phenotypic manifestations of the biofilm may also elicit lifestyle-dependent adaptive responses to selective pressures. In this work, an experimental evolution model was used to study the adaptation to a biofilm lifestyle in Pseudomonas aeruginosa PA14. The serial passage of...

Topics

• Biofilms
• Pseudomonas aeruginosa
• Cyclic GMP
• Mutation
• Signal Transduction
• Bacterial Proteins