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m6A-Mediated Methylation Patterns and Their Association With Obstructive Sleep Apnea in Lung Adenocarcinoma.

Cancer reports (Hoboken, N.J.) - 1 Sept 2025

Xia Lei, Chai Zhuodong, Wei Xiaoying, Wei Yuan, Zeng Daxiong, Jiang Junhong, Li Jing

Abstract excerpt

BACKGROUND: Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6-methyladenosine (m6A) modification, especially in obstructive sleep apnea-hypopnea syndrome (OSAHS) within LUAD, is not well understood. METHODS: This study examined m6A modification patterns in 973 LUAD patients using 23 regulatory genes. Unsupervised clustering categorized patients...

Topics

Humans
Adenocarcinoma of Lung
Lung Neoplasms
Sleep Apnea, Obstructive
Male
Adenosine
Female
Middle Aged
Tumor Microenvironment
Epigenesis, Genetic
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prognosis

Biomarkers, Tumor

Mutation

Gene Expression Regulation, Neoplastic

Source

Open in PubMed Open full text

Identifiers

PMID: 40916616
DOI: 10.1002/cnr2.70344
PMCID: PMC12415354

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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