AOP report: adverse outcome pathway network for developmental androgen signaling inhibition leading to short anogenital distance in male offspring

Abstract excerpt

This report outlines an adverse outcome pathway network (AOPN) linking reduced androgen signaling during the fetal masculinization programming window to shortened anogenital distance (AGD) at birth. In mammals such as mice, rats, and humans, the AGD is approximately twice as long in males as in females, with the length driven by androgen-dependent differentiation of the male phenotype. Impaired androgen signaling...

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