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Article

Biventricular Dysfunction in Knock-in Mice With Dsg2 Variants Specific for Japanese Arrhythmogenic Right Ventricular Cardiomyopathy.

Circulation journal : official journal of the Japanese Circulation Society - 25 Dec 2025

Zankov Dimitar P, Batbaatar Mend Amar, Tsuchimochi Hirotsugu, Saito Shigeyoshi, Zhu Ming, Fujihara Yoshitaka, Sonoda Keiko, Ohno Seiko

Abstract excerpt

BACKGROUND: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited disease with a poor prognosis and no curative therapy. It may present as arrhythmogenic sudden cardiac death and inevitably progress to terminal heart failure due to the loss of contractile tissue. This study aimed to generate knock-in (KI) mice carrying the 2 genetic variants (DSG2 p.R292C and p.D494A) most frequently found in...

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Arrhythmogenic Right Ventricular Dysplasia
Desmoglein 2
Disease Models, Animal
East Asian People

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Knock-In Techniques

Myocytes, Cardiac

Source

Identifiers

PMID: 40887256
DOI: 10.1253/circj.CJ-25-0269

Genes

DSG2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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