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Biofilm development in three-dimensional models infected with Trichophyton rubrum

29 Aug 2025

Abstract excerpt

ABSTRACT Dermatophytes are keratinophilic filamentous fungi that cause dermatophytosis, and the main etiological agents can be anthropophilic and zoophilic. Several virulence factors are involved in the pathogenesis of dermatophytosis, including the formation of fungal biofilms. In this context, three-dimensional (3D) models, such as spheroids and reconstructed human skin (RHS), have gained prominence, as they...

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PMID: 40879668
DOI: 10.1128/spectrum.01087-25

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