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Identification and validation of oxidative stress signature genes in the trabecular meshwork of glaucoma

25 Aug 2025

Abstract excerpt

Oxidative stress (OS) plays an important role in trabecular meshwork (TM) dysfunction in glaucoma, but its molecular mechanism remains unclear. We integrated the GSE27276 dataset and OS-related gene sets from GeneCards to screen 61 differentially expressed OS-related genes (DEOSGs). Functional enrichment analysis revealed that these genes are primarily involved in inflammatory and OS-related signaling pathways,...

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PMID: 40855175
DOI: 10.1038/s41598-025-16534-z

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