Inhibition of craniosynostosis and premature suture fusion in Twist1 mutant mice with RNA nanoparticle gene therapy.

Abstract excerpt

Craniosynostosis is a common birth defect affecting 1 of the 2200 live births causing severe skull and cognitive defects, due to premature cranial suture fusion. The current surgical treatments require invasive calvaria vault remodeling and cranial bone resection in the baby. We demonstrate that inhibition of miR-200a in PMIS-miR-200a mice results in coronal suture fusion (craniosynostosis). Therefore, we use...

Topics

• Animals
• Twist-Related Protein 1
• Craniosynostoses
• Nanoparticles
• Mice
• Cranial Sutures
• Genetic Therapy