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Article

Placental epigenetic clocks derived from crowdsourcing: Implications for the study of accelerated aging in obstetrics

23 Jul 2025

Abstract excerpt

Epigenetic gestational age acceleration has been implicated in obstetric syndromes including preeclampsia, yet robust conclusions require accurate and unbiased epigenetic age models. Herein, we curated 1,842 public placental methylomes and organized a DREAM challenge to develop models of gestational age. Participants were blinded to the test data that we generated from 384 placentas encompassing normal and...

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PMID: 40822353
DOI: 10.1016/j.isci.2025.113181

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