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Article

APTIMA mRNA vs. DNA-Based HPV Assays: Analytical Performance Insights from a Resource-Limited South African Setting.

International journal of molecular sciences - 1 Aug 2025

Nkwinika Varsetile Varster, Amissah Kelvin Amoh, Rakgole Johnny Nare, Khaba Moshawa Calvin, Magwira Cliff Abdul, Lebelo Ramokone Lisbeth

Abstract excerpt

Cervical cancer remains a major health burden among women in sub-Saharan Africa, where screening is often limited. Persistent high-risk human papillomavirus (HR-HPV) infection is the principal cause, highlighting the need for accurate molecular diagnostics. This cross-sectional study evaluated the analytical performance of one mRNA assay, APTIMA® HPV assay (APTIMA mRNA), and two DNA-based assays, the Abbott...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40806579
DOI: 10.3390/ijms26157450
PMCID: PMC12347973

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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