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Article

Hysteresis of the lower esophageal sphincter: relevance to the pathogenesis of esophageal achalasia and its phenotypes.

American journal of physiology. Gastrointestinal and liver physiology - 1 Sept 2025

Jain Anand S, Breaux William, Robertson Joshua K, Kim Se-Eun, McAdoo Billynda, Keilin Steven, Fernandez Felix, Srinivasan Shanthi, Mittal Ravinder K

Abstract excerpt

Hysteresis is a change in strain for a given repeated stress; it is a material property of the viscoelastic tissues. We aimed to determine hysteresis of the esophagogastric junction (EGJ) in patients with esophageal achalasia and differences in EGJ hysteresis in different achalasia phenotypes. In a cross-sectional study design, we measured the change in EGJ distensibility index (DI) with repeated distensions (a...

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Identifiers

PMID: 40796219
DOI: 10.1152/ajpgi.00089.2025
PMCID: PMC12413816

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