Integrative single-cell and exosomal multi-omics uncovers SCNN1A and EFNA1 as non-invasive biomarkers and drivers of ovarian cancer metastasis

Abstract excerpt

Background: Ovarian cancer (OV) is the deadliest gynecologic malignancy owing to its late diagnosis and high metastatic propensity. Current biomarkers lack sufficient sensitivity and specificity for the detection of early-stage cancer. To address this gap, we integrated single-cell transcriptomic profiling of tumor tissues with analysis of circulating exosomal RNA, aiming to uncover candidate markers that reflect...

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