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Screening, identification, and experimental validation of SUMOylation biomarkers in Parkinson’s disease

8 Aug 2025

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pathogenesis remains unclear. This study aimed to investigate the relationship between SUMOylation and PD. METHODS: The analysis included the GSE22491 dataset, GSE18838 dataset, and 189 SUMO...

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PMID: 40781725
DOI: 10.1186/s41065-025-00525-1

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