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Article

Genetic and polygenic contributions to familial hypercholesterolemia in Thailand: Implications for diagnosis and lipid management.

Journal of clinical lipidology - 1 Jan 2025

Pasookhush Phongthana, Surawit Apinya, Suta Sophida, Pumeiam Sureeporn, Mongkolsucharitkul Pichanun, Pinsawas Bonggochpass, Ophakas Suphawan, Mayurasakorn Korapat

Abstract excerpt

BACKGROUND: Familial hypercholesterolemia (FH) is a major risk factor for cardiovascular diseases; however, the issue of underdiagnosis remains a global challenge. This study investigates the prevalence of FH-associated variants in Thailand and examines the clinical and lipid profile characteristics of variant carriers to improve diagnostic strategies. METHODS: We analyzed the genetic data of 4879 participants...

Read the complete abstract on PubMed

Topics

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Share to Cholesterol, LDL
Share to Hyperlipoproteinemia Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipids

Share to Multifactorial Inheritance

Share to Polymorphism, Single Nucleotide

Share to Proprotein Convertase 9

Share to Receptors, LDL

Share to Thailand

Source

Identifiers

PMID: 40713324
DOI: 10.1016/j.jacl.2025.06.020

Genes

FH
APOB
LDLR
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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