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Q221K mutation in VP2 drives antigenic shift of infectious bursal disease virus

10 Jul 2025

Abstract excerpt

Introduction: Infectious bursal disease (IBD) is a severe immunosuppressive disease caused by the infection of infectious bursal disease virus (IBDV) in chicken. Recently, an emerging mutant named novel variant IBDV (nVarIBDV) has rapidly spread in China and become a prevalent strain. However, little is known about the unique antigenic sites of nVarIBDV escaped from current IBDV vaccines. Methods: Here, the...

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PMID: 40709180
DOI: 10.3389/fimmu.2025.1600371

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