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Elevated NPM1 and FBL expression correlates with prostate cancer aggressiveness and progression

24 Jul 2025

Abstract excerpt

The nucleolus is a membrane-less body present in the nucleus of the cell. The nucleolus is mainly involved in ribosomal RNA (rRNA) transcription and ribosome biogenesis for protein translation. During cancer formation, nucleolar morphology is altered, and many nucleolar proteins are expressed at a higher level, leading to enhanced ribosome biogenesis and protein translation, which supports cancer aggressiveness,...

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PMID: 40705480
DOI: 10.1002/path.6447

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