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The defensome of prokaryotes in aquifers

14 Jul 2025

Abstract excerpt

Groundwater harbors a pristine biosphere where microbes co-evolve with less human interference, yet the ancient and ongoing arms race between prokaryotes and viruses remains largely unknown in such ecosystems. Based on our recent nationwide groundwater monitoring campaign across China, we construct a metagenomic groundwater prokaryotic defensome catalogue (GPDC), encompassing 190,810 defense genes, 90,824 defense...

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PMID: 40659683
DOI: 10.1038/s41467-025-61467-w

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