Genetic and clinical insights into acute kidney injury in maturity‑onset diabetes of the young caused by the ABCC8 c.2500C>T mutation: Potential risk factors associated with SGLT2 inhibitors

Abstract excerpt

Mature‑onset diabetes of the young (MODY) is an autosomal dominant genetic disease that is typically diagnosed during childhood or early adolescence. The primary pathogenesis of MODY involves gene mutations that impair insulin synthesis and/or secretion by islet β cells, rendering the condition independent of insulin resistance. A family with the MODY‑12 phenotype caused by an ATP‑binding cassette subfamily C...

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