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Transcriptional Insights into Anti-Adhesion of Human Milk Oligosaccharides Against E. coli O157:H7: Decoy Effects and Immunomodulatory

4 Jul 2025

Abstract excerpt

Human milk oligosaccharides (HMOs) exhibit potential in preventing enteric infections; however, the specific mechanisms by which HMOs act against Escherichia coli O157:H7 remain to be elucidated. This study investigated the anti-infective effects of HMOs using HT-29 cell models and transcriptomic analysis. Bacterial interaction assays showed that 10 mg/mL HMOs reduced E. coli adhesion by over 85%, primarily...

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PMID: 40613459
DOI: 10.1021/acs.jafc.5c02449

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