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Identification of parthanatos-related molecular subtypes and development of prognostic risk models in ovarian cancer based on multi-omics analysis

2 Jul 2025

Abstract excerpt

Ovarian cancer (OC) remains the most lethal gynecologic malignancy due to late-stage diagnosis, high recurrence rates, and chemoresistance. Parthanatos, a distinct caspase-independent form of programmed cell death mediated by poly (ADP-ribose) (PAR), plays a critical role in DNA damage response and tumor progression. In this study, we identified parthanatos-related genes (PRG) associated with OC prognosis based...

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PMID: 40605104
DOI: 10.1186/s13048-025-01726-y

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