Article
Biomarkers of psychological stress are associated with increased susceptibility to the development of breast and prostate cancer in BRCA1/2 mutation carriers.
British journal of cancer - 1 Sept 2025
Flaherty R L, Falcinelli M, Hesketh A R, Patel B A, Bancroft E, Page E, Eeles R, Flint M S
Abstract excerpt
BACKGROUND: Epidemiological studies have linked psychological stress with an increased risk of breast cancer, however few studies have linked stress hormone signalling to cancer initiation mechanistically. This may be particularly pertinent in populations already at risk due to mutations in the cancer predisposition genes BRCA1/2. METHODS: Here we employ BRCA1/2 knockdown in breast and prostate epithelial cells...
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