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The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer

2 Jul 2025

Abstract excerpt

The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance mechanisms. Novel approaches to overcome these drawbacks comprise the utilization of ionophores and metalliferous chelators to change the concentration of trace metal elements in cancer cells. As the concept of cuproptosis emerged, it might be a novel strategy to enhance the curative...

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PMID: 40601654
DOI: 10.1371/journal.pone.0324389

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