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Article

The potential role of cuproptosis-related genes for therapy and immunoregulation in pan-cancer.

PloS one - 1 Jan 2025

Zhou Jianpeng, Wang Chuanlei, Zhi Yao, Li Jia

Abstract excerpt

The primary drawbacks of current cancer therapies are lower selectivity for cancer cells, more side effects, and obscure resistance mechanisms. Novel approaches to overcome these drawbacks comprise the utilization of ionophores and metalliferous chelators to change the concentration of trace metal elements in cancer cells. As the concept of cuproptosis emerged, it might be a novel strategy to enhance the curative...

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Source

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Identifiers

PMID: 40601654
DOI: 10.1371/journal.pone.0324389
PMCID: PMC12220987

Genes

SLC31A1
DLAT
DLD
FDX1
LIAS
LIPT1
PDHA1
PDHB

Provenance

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