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Article

Pan-cancer patterns of cuproptosis markers reveal biologically and clinically relevant cancer subtypes

31 Jan 2023

Abstract excerpt

Cuproptosis is a newly discovered type of cell death triggered by copper accumulation. Here we exhibited the genetic profiles of 10 cuproptosis-associated genes (CuAGs) across 21 cancer types. Only 8.0% (627/7839) of tumors possessed at least 1 mutation on CuAGs, while the copy number amplifications or deletions on the alleles of CuAGs were ubiquitous. Generally, the expression of CuAGs showed heterogeneity...

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PMID: 36721175
DOI: 10.1186/s40364-022-00446-5

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