Fecal Microbial Community Profiling Allows Discrimination of Phenotype and Treatment Response in Pediatric Crohn's Disease and Ulcerative Colitis-An International Meta-Analysis.

doi:10.1093/ibd/izaf135

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Fecal Microbial Community Profiling Allows Discrimination of Phenotype and Treatment Response in Pediatric Crohn's Disease and Ulcerative Colitis-An International Meta-Analysis.

Inflammatory bowel diseases - 1 Sept 2025

Aldrian Denise, Pollio Adam, Mayerhofer Christoph, Diederen Kay, Jacobs Jonathan P, Pai Nikhil, Szamosi Jake C, Hart Lara, Turner Dan, Del Chierico Federica, Cardile Sabrina, Grigoryan Zoya, Chen Lea Ann, Hurych Jakub, Cinek Ondrej, Taddei Carla R, Schwerd Tobias, Wine Eytan, Griffiths Anne M, Müller Thomas, Vogel Georg F

Abstract excerpt

BACKGROUND AND AIMS: The pathophysiology of pediatric inflammatory bowel disease (PIBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), is not entirely understood. Dysregulation of the intestinal microbiome is recognized as both a disease-driving and a potential therapeutic target. This study aimed to systematically analyze gut microbiome compositions and its applicability as a biomarker for...

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PMID: 40583454
DOI: 10.1093/ibd/izaf135
PMCID: PMC12455605

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