The DEAD-box RNA helicase 27 negatively regulates the replication of porcine reproductive and respiratory syndrome virus by mediating GP2a autophagy degradation and inducing interferon-β production

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) causes severe economic losses to the swine industry, with its replication and immune evasion mechanisms remaining incompletely understood. While DEAD-box helicases (DDXs) are known to either promote or inhibit viral infections, no prior studies have explored the role of DDX27 in viral pathogenesis. Here, we investigated the role of DDX27 in PRRSV...

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