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Article

Confidence-linked and uncertainty-based staged framework for phenotype validation using large language models.

Journal of the American Medical Informatics Association : JAMIA - 1 Aug 2025

Lee Sumin, Lee Hyeok-Hee, Lee Hokyou, Yum Kyu Sun, Baek Jang-Hyun, Khil Jaewon, Lee Jaeyong, Shin Sojung, Cho Minsung, Ahn Na Yeon, You Seng Chan, Kim Hyeon Chang

Abstract excerpt

OBJECTIVES: This study develops and validates the confidence-linked and uncertainty-based staged (CLUES) framework by integrating large language models (LLMs) with uncertainty quantification to assist manual chart review while ensuring reliability through a selective human review. MATERIALS AND METHODS: The CLUES framework assesses stroke-related hospitalizations using imaging reports for 1739 patients across 24...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40574695
DOI: 10.1093/jamia/ocaf099
PMCID: PMC12277694

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