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Comparative genomics reveals key adaptive mechanisms in pathogen host-niche specialization

6 Jun 2025

Abstract excerpt

Introduction Understanding the key factors that enable bacterial pathogens to adapt to new hosts is crucial, as host-microbe interactions not only influence host health but also drive bacterial genome diversification, thereby enhancing pathogen survival in various ecological niches. Methods We conducted a comparative genomic analysis of 4,366 high-quality bacterial genomes isolated from various hosts and...

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PMID: 40547794
DOI: 10.3389/fmicb.2025.1543610

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