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Minimizing detection bias of somatic mutations in a highly heterozygous oak genome.

G3 (Bethesda, Md.) - 6 Aug 2025

Xian Wenfei, Carbonell-Bejerano Pablo, Rabanal Fernando A, Bezrukov Ilja, Reymond Philippe, Weigel Detlef

Abstract excerpt

Somatic mutations are particularly relevant for long-lived organisms. Sources of somatic mutations include imperfect DNA repair, replication errors, and exogenous damage such as ultraviolet radiation. A previous study estimated a surprisingly low number of somatic mutations in a 234-year-old individual of the pedunculate oak (Quercus robur), known as the Napoleon Oak. It has been suggested that the true number of...

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PMID: 40543050
DOI: 10.1093/g3journal/jkaf143
PMCID: PMC12341919

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