Article
The great phage escape: Activating and escaping lactococcal antiphage systems.
Proceedings of the National Academy of Sciences of the United States of America - 17 Jun 2025
Mosterd Cas, Grafakou Andriana, Ortiz Charneco Guillermo, de Waal Paul P, van Rijswijck Irma M H, van Peij Noël N M E, Péchoux Christine, Kulakauskas Saulius, Cambillau Christian, Mahony Jennifer, van Sinderen Douwe
Abstract excerpt
In recent years, the number of newly discovered systems that bacteria use to combat bacteriophages is increasing at an impressive rate. To obtain mechanistic insights into several antiphage systems identified in previous studies, we isolated 66 phage escape mutants which had become insensitive to 13 distinct, plasmid-encoded lactococcal phage resistance systems (i.e. Rhea, Kamadhenu, Rugutis, Audmula, PARIS, type...
Read the complete abstract on PubMedTopics
- Bacteriophages
- Mutation
- Bacterial Proteins
- Lactococcus