Article
Detecting SARS-CoV-2 cryptic lineages using publicly available whole genome wastewater sequencing data.
PLoS pathogens - 1 Jun 2025
Suarez Reinier, Gregory Devon A, Baker David A, Rushford Clayton A, Hunter Torin L, Minor Nicholas R, Russ Clayton M, Copen Emma E, O'Connor David H, Johnson Marc C
Abstract excerpt
Beginning in early 2021, unique and highly divergent lineages of SARS-CoV-2 were sporadically found in wastewater sewersheds using a sequencing strategy focused on amplifying the most rapidly evolving region of SARS-CoV-2, the receptor binding domain (RBD). Because these RBD sequences did not match known circulating strains and their source was not known, we termed them "cryptic lineages". To date, more than 20...
Read the complete abstract on PubMedTopics
- SARS-CoV-2
- Wastewater
- COVID-19
- Humans
- Genome, Viral
- Whole Genome Sequencing