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Construction of molecular subtype and prognostic model for gastric cancer based on nucleus-encoded mitochondrial genes.

Scientific reports - 18 Nov 2024

Wang Xu, Li Sainan, Shen Yuhuan, Cao Li, Lu Yajuan, Cao Jinghao, Liu Yingchao, Deng Aoli, Yang Jiyun, Wang Tongtong

Abstract excerpt

Gastric cancer (GC) is a common digestive system cancer, characterized by a significant mortality rate. Mitochondria is an indispensable organelle in eukaryotic cells. It was previously revealed that a series of nucleus-encoded mitochondrial genes (NMG) mutations and dysfunctions potentially contribute to the initiation and progression of GC. However, the correlation between NMG mutations and survival outcomes...

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Biomarkers, Tumor
Cell Nucleus
Databases, Genetic
Gene Expression Regulation, Neoplastic
Genes, Mitochondrial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Stomach Neoplasms

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PMID: 39557952
DOI: 10.1038/s41598-024-78729-0
PMCID: PMC11574080

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