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Article

HLA diversity and signatures of selection in the Maniq, a nomadic hunter-gatherer population in Southern Thailand.

Immunogenetics - 9 Jun 2025

Schaschl Helmut, Herzog Tobias, Oberreiter Victoria, Kutanan Wibhu, Jakobsson Mattias, Larena Maximilian

Abstract excerpt

The Maniq, a small and isolated nomadic hunter-gatherer population from the rainforests of Southern Thailand, offer a unique context for investigating how demographic history, genetic drift, and pathogen-driven selection shape human leucocyte antigen (HLA) diversity. Using high-coverage whole-genome data from 21 individuals (12 unrelated), we genotyped HLA alleles with HLA-HD and T1K, identifying 32 alleles in...

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Identifiers

PMID: 40488890
DOI: 10.1007/s00251-025-01380-0
PMCID: PMC12148999

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