Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Pseudohypoxia caused by germline genetic alterations in the VHL gene is associated with increased diabetes and cardiovascular risk: a UK biobank study.

Cardiovascular diabetology - 4 Jun 2025

Halperin Reut, Horwitz Roi, Schwarz Yair, Tirosh Amit

Abstract excerpt

BACKGROUND: Von Hippel-Lindau protein deficiency leads to cellular and tissue false sense of hypoxia (pseudohypoxia), driving erythropoiesis, angiogenesis, and dysglycemia. The impact of partial VHL protein deficiency, caused by heterozygous VHL gene alterations on diabetes and cardiovascular risk has not been investigated. Hence, in the current study we assessed a possible association between VHL genotype and...

Topics

Join the communities discussing this publication.

Biological Specimen Banks
Cardiovascular Diseases
Diabetes Mellitus
Heart Disease Risk Factors
UK Biobank

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

von Hippel-Lindau Disease

Von Hippel-Lindau Tumor Suppressor Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 40468346
DOI: 10.1186/s12933-025-02799-1
PMCID: PMC12139118

Genes

VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pseudohypoxia caused by germline genetic alterations in the VHL gene is associated with increased diabetes and cardiovascular risk: a UK biobank study.PMID 40468346Read ↗

Molecular basis of the VHL hereditary cancer syndrome.Semantic proximity Read ↗

Von Hippel–Lindau Disease: Molecular Pathological Basis, Clinical Criteria, Genetic Testing, Clinical Features of Tumors and TreatmentSemantic proximity Read ↗

The Role of VHL in the Development of von Hippel-Lindau Disease and Erythrocytosis.Semantic proximity Read ↗

von Hippel-Lindau Disease: an UpdateSemantic proximity Read ↗

The Endothelial Landscape and Its Role in Von Hippel-Lindau Disease.Semantic proximity Read ↗

The genetic differences between types 1 and 2 in von Hippel-Lindau syndrome: comprehensive meta-analysis.Semantic proximity Read ↗

Von Hippel-Lindau disease.Semantic proximity Read ↗

[From gene to disease; Von Hippel-Lindau disease].Semantic proximity Read ↗

Is the P25L a "real" VHL mutation?Semantic proximity Read ↗

The Genomics and Genetics of Oxygen HomeostasisSemantic proximity Read ↗

A Nonsense Mutation in VHL Gene Causing Von Hippel-lindau Syndrome in a Large Chinese FamilySemantic proximity Read ↗

Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmataSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.