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Article

Assessment of the bidirectional causal association between frailty and allergic diseases.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Oct 2025

Fan Guo Zhen, Gao Jian Xiang, Hu Li Xin, Papadopoulos Nikolaos G, Qu Zheng Hai

Abstract excerpt

This study aimed to explore the potential causal relationship between frailty and allergic diseases through bidirectional Mendelian randomization (MR) analysis. Single-nucleotide polymorphisms (SNPs) were selected as instrumental variables from the genome-wide association studies summary data. The inverse variance weighted (IVW) method was used as the main analysis method, and the MR-Egger regression and weighted...

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PMID: 40444436
DOI: 10.1177/10815589251348911

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AR

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