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Article

Characterizing the preserved ratio impaired spirometry phenotype in all severities of asthma.

Respiratory medicine - 1 Aug 2025

Cottini Marcello, Poto Remo, Bhattacharjee Atanu, Galant Stanley, Lipworth Brian, Gaillard Erol A, Greig Robert, Berti Alvise, Lombardi Carlo, Menzella Francesco, Ventura Laura, Comberiati Pasquale, Chan Rory

Abstract excerpt

INTRODUCTION: The preserved ratio impaired spirometry (PRISm) phenotype is characterized by a maintained FEV1/FVC ratio ≥70 but an abnormal FEV1<80 % predicted. Small airways dysfunction (SAD) is common amongst asthmatics and is associated with poorer clinical outcomes. SAD can be assessed using oscillometry as resistance between 5 and 20Hz (Rrs5-20), reactance at 5Hz (X5) and area under the reactance curve (AX)....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40441497
DOI: 10.1016/j.rmed.2025.108180

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