The Role of G Protein-Coupled Receptors in the Regulation of Orthopaedic Diseases by Gut Microbiota

Abstract excerpt

Exercise and diet modulate the gut microbiota, which is involved in the regulation of orthopaedic diseases and synthesises a wide range of metabolites that modulate cellular function and play an important role in bone development, remodelling and disease. G protein-coupled receptors (GPCRs), the largest family of transmembrane receptors in the human body, interact with gut microbial metabolites to regulate...

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