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Genetic Basis of Motor Neuron Diseases: Insights, Clinical Management, and Future Directions

20 May 2025

Abstract excerpt

Motor neuron diseases (MNDs) are a heterogeneous group of neurodegenerative disorders characterized by the progressive loss of motor neurons, resulting in debilitating physical decline. Advances in genetics have revolutionized the understanding of MNDs, elucidating critical genes such as SOD1, TARDBP, FUS, and C9orf72, which are implicated in their pathogenesis. Despite these breakthroughs, significant gaps...

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PMID: 40430041
DOI: 10.3390/ijms26104904

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