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Early establishment and life course stability of sex biases in the human brain transcriptome

26 May 2025

Abstract excerpt

To elaborate on the origins of the established male-female differences in several brain-related phenotypes, we assessed the patterns of transcriptomic sex biases in the developing and adult human forebrain. We find an abundance of sex differences in expression (sex-DEs) in the prenatal brain, driven by both hormonal and sex-chromosomal factors, and considerable consistency in the sex effects between the...

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PMID: 40425010
DOI: 10.1016/j.xgen.2025.100890

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