Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applications

21 May 2025

Abstract excerpt

The niche microenvironment plays a crucial role in regulating the fate of normal skin stem cells (SSCs) and cancer stem cells (CSCs). Therapeutically targeting the CSC niche holds promise as an effective strategy; however, the dual effects of shared SSC niche signaling in CSCs have contributed to the aggressive characteristics of tumors and poor survival rates in skin cancer patients. The lack of a clear...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Hippo pathway signaling and YAP/TAZ
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40399946
DOI: 10.1186/s12943-025-02289-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Double-sided niche regulation in skin stem cell and cancer: mechanisms and clinical applicationsPMID 40399946Read ↗

Niche interactions in epidermal stem cellsSemantic proximity Read ↗

Stem cells of the human epidermis and their niche: composition and function in epidermal regeneration and carcinogenesisSemantic proximity Read ↗

Wnt/β-Catenin Signaling Pathway in Skin Carcinogenesis and TherapySemantic proximity Read ↗

Cancer Microenvironment: What Can We Learn from the Stem Cell NicheSemantic proximity Read ↗

Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomesSemantic proximity Read ↗

Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the SkinSemantic proximity Read ↗

Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancerSemantic proximity Read ↗

SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial CancersSemantic proximity Read ↗

Recent advances on skin‐resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti‐aging and cancer therapiesSemantic proximity Read ↗

Cellular Heterogeneity and Plasticity of Skin Epithelial Cells in Wound Healing and TumorigenesisSemantic proximity Read ↗

Cancer stem cells, epigenetics, tumor microenvironment and future therapeutics in cutaneous malignant melanoma: a review.Semantic proximity Read ↗

Heterogeneous Stem Cells in Skin Homeostatis and Wound RepairSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.