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Article

GJB2 as a novel prognostic biomarker associated with immune infiltration and cuproptosis in ovarian cancer

15 May 2025

Abstract excerpt

Cuproptosis, a recently identified copper-dependent cell death mechanism, remains poorly unexplored in ovarian cancer (OC). This study systematically evaluates clinically significant cuproptosis-related genes (CRGs) as potential prognostic biomarkers in OC. Cox regression analysis and LASSO algorithms were used to develop a prognostic risk model incorporating 5 CRGs ( CD8B2 , GJB2 , GRIP2 , MELK , and PLA2G2D )...

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PMID: 40375037
DOI: 10.1007/s10495-025-02119-8

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