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FokI polymorphism of the vitamin D receptor gene: Linking COVID-19 risk to genetic susceptibility in children.

Cytokine - 1 Jul 2025

Mohamed Amal Ahmed, Alanazi Abdullah Taher, Ahmed Hoda H, Elfiky Samar, Abdel Ghafar Muhammad T, Maher Ingy, Taha Sherin A, AbuRahma Mohammed Zakaria Ali, Elagawy Waleed, Mohareb Dina A, Rawy Abeer M, Abostate Heba M, Youssef Amira AlSayed, Elsayed Dalia Saeed, Abdel-Hamid Rasha M

Abstract excerpt

BACKGROUND: Vitamin D receptor (VDR), influenced by gene polymorphisms like FokI, may affect susceptibility to infections, including coronavirus disease 2019 (COVID-19). Since studies in children are limited, we aimed to analyze the correlation between the VDR FokI variant and both the incidence and severity of COVID-19 in Egyptian children. METHODS: Seventy-seven COVID-19-positive and 107 COVID-19-negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40367829
DOI: 10.1016/j.cyto.2025.156958

Genes

VDR
CRP
TNF

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