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A Direct Comparative Analysis of HPV DNA with Single-Molecule RNA and p16INK4a Protein Expression in Lichen Sclerosus: Implications for Diagnostics and Pathogenesis

1 Apr 2025

Abstract excerpt

Introduction: Emerging evidence suggests a relationship between chronic, intermittent, occluded exposure of a susceptible epithelium to urine and male genital lichen sclerosus (MGLSc), although human papillomavirus (HPV) may also play a role. Aims and methods: detection. Results: staining. Discussion: HPV DNA was detected in a mosaic pattern across the prepuce, with no significant differences between MGLSc and...

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PMID: 40330849
DOI: 10.1016/j.xjidi.2025.100367

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